I haven't really seen a lot of documentation on how to read an XLS file into Coldfusion. Luckily, one of my colleagues was able to point me in the right direction. I am now here to write up a blog post for future reference.
Once you set up the new datasource in the CF Administrator (see comments below), it's really simple (at least more simple than parsing through the other file formats that I've had to do far). Basically, we just read it in as a query: